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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHL12
All Species:
24.85
Human Site:
S175
Identified Species:
45.56
UniProt:
Q53G59
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53G59
NP_067646.1
568
63277
S175
H
E
E
F
I
L
L
S
Q
G
E
V
E
K
L
Chimpanzee
Pan troglodytes
XP_001149345
684
76181
P285
S
E
E
F
M
L
L
P
A
N
Q
L
I
D
I
Rhesus Macaque
Macaca mulatta
XP_001094324
702
77633
S309
H
E
E
F
I
L
L
S
Q
G
E
V
E
K
L
Dog
Lupus familis
XP_537119
568
63260
S175
H
E
E
F
I
L
L
S
Q
G
E
V
E
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BZM0
568
63228
S175
H
E
E
F
I
L
L
S
Q
G
E
V
E
K
L
Rat
Rattus norvegicus
Q8R2H4
568
63244
S175
H
E
E
F
I
L
L
S
Q
G
E
V
E
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518122
290
31726
Chicken
Gallus gallus
XP_419251
558
62467
N165
H
E
E
F
I
L
L
N
Q
E
E
V
E
K
L
Frog
Xenopus laevis
Q6NRH0
564
63190
H171
H
E
E
F
M
L
L
H
Q
E
E
V
E
K
L
Zebra Danio
Brachydanio rerio
Q5U374
564
62914
S171
Q
E
E
F
M
L
L
S
Q
S
E
V
E
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUU5
623
68905
P214
S
E
E
F
L
L
L
P
V
G
Q
L
V
D
I
Honey Bee
Apis mellifera
XP_397065
620
68991
P221
S
E
E
F
L
L
L
P
V
G
Q
L
V
D
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180470
684
75689
T254
Y
T
E
Q
V
E
V
T
V
E
N
V
Q
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
37.8
80.9
99.8
N.A.
99.3
99.4
N.A.
50.3
87.1
91.5
89.7
N.A.
39.9
40.4
N.A.
40.6
Protein Similarity:
100
53.6
80.9
100
N.A.
99.8
99.8
N.A.
51
91
96.6
95.2
N.A.
57.9
57.7
N.A.
55.9
P-Site Identity:
100
33.3
100
100
N.A.
100
100
N.A.
0
86.6
80
80
N.A.
40
40
N.A.
20
P-Site Similarity:
100
60
100
100
N.A.
100
100
N.A.
0
93.3
86.6
86.6
N.A.
66.6
66.6
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
24
0
% D
% Glu:
0
85
93
0
0
8
0
0
0
24
62
0
62
8
0
% E
% Phe:
0
0
0
85
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
54
0
0
0
0
0
% G
% His:
54
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
47
0
0
0
0
0
0
0
8
0
24
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
62
0
% K
% Leu:
0
0
0
0
16
85
85
0
0
0
0
24
0
0
70
% L
% Met:
0
0
0
0
24
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
24
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
8
0
0
0
0
62
0
24
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
24
0
0
0
0
0
0
47
0
8
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
8
0
24
0
0
70
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _